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Chronic Inflammatory Diseases: Are We Ready for Microbiota-based Dietary Intervention?
Emilie Viennois1, Andrew T Gewirtz1, Benoit Chassaing2
1Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.
Cellular and Molecular Gastroenterology and Hepatology
|March 6, 2019
Summary
Emerging research shows intestinal microbiota dysregulation contributes to chronic inflammatory diseases. Diet significantly impacts this relationship, prompting questions about personalized microbiota-based dietary interventions for treatment.
Area of Science:
- Microbiology
- Gastroenterology
- Immunology
Background:
- The intestinal microbiota plays a crucial role in maintaining host health.
- Dysregulation of host-microbiota interactions is linked to chronic inflammatory diseases like inflammatory bowel diseases, colorectal cancer, and metabolic syndrome.
- Specific bacterial species can influence disease outcomes.
Purpose of the Study:
- To review recent literature on the interplay between intestinal microbiota, diet, and disease.
- To evaluate the potential for personalized dietary interventions based on microbiota composition for treating chronic inflammatory diseases.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of studies investigating microbiota composition, dietary factors, and chronic inflammatory diseases.
- Synthesis of evidence regarding the host-microbiota relationship and its modulation by diet.
Main Results:
- Diet is a primary factor influencing intestinal microbiota composition.
- Accumulating evidence supports the link between microbiota dysregulation and chronic inflammatory conditions.
- Identification of specific bacterial species associated with particular clinical outcomes.
Conclusions:
- Understanding the microbiota-diet-disease axis is advancing rapidly.
- The readiness for personalized dietary interventions based on microbiota composition for treating chronic inflammatory diseases remains an open question requiring further investigation.
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