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Thyroid function in hyperemesis gravidarum.

S A Bober, A C McGill, W M Tunbridge

    Acta Endocrinologica
    |March 1, 1986
    PubMed
    Summary
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    Severe hyperemesis gravidarum, a condition causing persistent vomiting in pregnancy, can transiently elevate free thyroxine levels. These thyroid function abnormalities typically resolve spontaneously as the condition improves and after childbirth.

    Area of Science:

    • Endocrinology
    • Obstetrics
    • Reproductive Medicine

    Background:

    • Hyperemesis gravidarum is characterized by severe nausea and vomiting during pregnancy.
    • It necessitates hospitalization and intravenous therapy.
    • Differential diagnosis excludes other causes of vomiting.

    Purpose of the Study:

    • To investigate thyroid function in patients diagnosed with hyperemesis gravidarum.
    • To determine if thyroid parameter abnormalities are associated with hyperemesis gravidarum.
    • To assess the transient nature of any observed thyroid dysfunction.

    Main Methods:

    • Studied twenty-five patients admitted for severe persistent vomiting (hyperemesis gravidarum).
    • Measured serum free thyroxine levels upon admission.

    Related Experiment Videos

  • Monitored nine other thyroid parameters longitudinally throughout pregnancy and post-partum.

    • Main Results:

    • Ten out of twenty-five (40%) patients presented with elevated free thyroxine levels on admission.
    • Free thyroxine levels normalized during pregnancy as symptoms improved.
    • Thyroid function remained normal postpartum.
    • Longitudinal data confirmed the transient nature of thyroid disturbances.

    Conclusions:

    • Elevated free thyroxine is a transient finding in a significant proportion of hyperemesis gravidarum cases.
    • Thyroid function disturbances associated with hyperemesis gravidarum are temporary and resolve spontaneously.
    • These findings suggest a link between hyperemesis gravidarum and transient thyroid dysfunction.