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Related Experiment Videos

Alfentanil anaesthesia in gall-bladder surgery.

J C Raeder, A Hole

    Acta Anaesthesiologica Scandinavica
    |January 1, 1986
    PubMed
    Summary

    High-dose alfentanil anesthesia in cholecystectomy patients led to adverse events like stiff chest and respiratory arrest. It did not provide additional benefits in blocking surgical stress responses.

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    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Alfentanil is an opioid analgesic used in anesthesia.
    • Optimizing anesthetic regimens is crucial for patient safety and surgical outcomes.

    Purpose of the Study:

    • To evaluate the efficacy of different alfentanil dosage schemes in blocking surgical stress response.
    • To assess the safety profile of varying alfentanil doses during cholecystectomy.

    Main Methods:

    • A study involving 25 patients undergoing elective cholecystectomy.
    • Comparison of five different alfentanil dosage schemes supplemented with thiopentone, pancuronium, and N2O/O2.
    • Serial measurements of serum cortisol and glucose, heart rate, and blood pressure to assess surgical stress response.

    Main Results:

    • No significant changes in serum cortisol, heart rate, or blood pressure during anesthesia and surgery across groups.
    • Significant increase in serum cortisol 2 hours postoperatively in all patients.
    • Significant elevation of serum glucose observed in most groups post-surgery.
    • High-dose alfentanil was associated with increased incidence of stiff chest and postoperative respiratory arrest.

    Conclusions:

    • High-dose alfentanil did not offer additional benefits in blunting the surgical stress response during cholecystectomy.
    • Increased alfentanil dosage correlated with higher risks of adverse respiratory events, including stiff chest and respiratory arrest.

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