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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
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α-MoO3 nanostructure on carbon cloth substrate for dopamine detection
D Murugesan1, K Moulaee2, G Neri2
1Department of Nanoscience and Technology, Bharathiar University, Coimbatore 641046, India.
Nanotechnology
|March 6, 2019
Summary
A novel electrochemical sensor utilizing orthorhombic molybdenum oxide (α-MoO3) nanostructures on carbon cloth (CC) offers enhanced dopamine detection. This sensor demonstrates superior sensitivity and a wider linear dynamic range for detecting dopamine in real samples.
Area of Science:
- Materials Science
- Electrochemistry
- Nanotechnology
Background:
- Flexible and conductive scaffolds are crucial for advanced electrochemical sensors.
- Orthorhombic molybdenum oxide (α-MoO3) possesses promising electrocatalytic properties.
- Carbon cloth (CC) offers a high surface area and excellent conductivity for sensor fabrication.
Purpose of the Study:
- To develop a sensitive and reliable electrochemical sensor for dopamine determination.
- To investigate the performance of α-MoO3 nanostructures integrated with CC.
- To evaluate the sensor's applicability in real-world samples.
Main Methods:
- Fabrication of α-MoO3 nanostructures on CC using reactive RF magnetron sputtering.
- Characterization using field emission scanning electron microscopy, X-ray diffraction, energy dispersive X-ray, and Raman spectroscopy.
- Electrochemical analysis via cyclic voltammetry, amperometry (AM), and square wave voltammetry (SWV).
Main Results:
- The α-MoO3/CC sensor exhibited enhanced sensitivity and a broader linear dynamic range for dopamine detection using SWV compared to AM.
- A low limit of detection (0.48 μM) was achieved.
- Satisfactory results were obtained for dopamine measurement in urine and pharmaceutical formulations.
Conclusions:
- The developed α-MoO3/CC electrochemical sensor is highly effective for sensitive dopamine detection.
- The combination of α-MoO3 nanostructures and CC provides a superior platform for electrochemical sensing.
- The sensor shows potential for practical applications in biological and pharmaceutical analysis.
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