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Updated: Jan 28, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Major lower limb amputations in Far North Queensland.
Alexander L Nesbitt1, Katherine Goodall1, Vrushank Bakshi2
1Department of Surgery, Cairns Hospital, Cairns, Queensland, Australia.
Major lower limb amputations are often due to diabetes complications. This study found patients in Far North Queensland are younger and more frequently diabetic, with higher rates among Indigenous populations.
Area of Science:
- Vascular Surgery
- Diabetology
- Public Health
Background:
- Major lower limb amputation is a significant procedure, often resulting from peripheral artery disease or diabetes mellitus.
- Significant variations in amputation rates exist globally and nationally.
- Understanding regional patient demographics is crucial for targeted interventions.
Purpose of the Study:
- To characterize patients undergoing major lower limb amputation in Far North Queensland.
- To compare this cohort with national and state data.
- To investigate demographic and clinical differences in the Indigenous population.
Main Methods:
- Retrospective review of a prospectively maintained database of 51 major lower limb amputations (January 2015 - January 2017).
- Collection of relevant clinical information.
- Comparative analysis with existing literature and Australian data.
Main Results:
- The average patient age was 59.5 years; over 70% had diabetes, and one-third required dialysis.
- Indigenous patients (23 of 51) were significantly younger (54.6 vs. 63.5 years) and more likely to be diabetic (91.3% vs. 65.2%).
- Arterial ulcer/gangrene was the most common indication (52.9%), but Indigenous patients more frequently underwent amputation due to sepsis (47.8% vs. 7.1%).
Conclusions:
- Major amputation patients in Far North Queensland are younger and more diabetic compared to Australian averages.
- Diabetes and renal disease are highly prevalent, particularly in the Indigenous patient group.
- Sepsis is a more common driver for amputation in Indigenous individuals.
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