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[The first 1000 days: an opportunity to reduce the burden of noncommunicable diseases]

José Manuel Moreno Villares1, María Carmen Collado2, Elvira Larqué3

  • 1Clínica Universidad de Navarra.

Nutricion Hospitalaria
|March 7, 2019
PubMed

Insights

The first 1,000 days of life, from conception to age two, are critical for long-term health. Optimal nutrition and a healthy gut microbiome during this period can prevent non-communicable diseases (NCDs).

Area of Science:

  • Developmental biology
  • Nutritional science
  • Public health

Background:

  • Early life development is influenced by genetics and environment, with long-term health risks like obesity and non-communicable diseases (NCDs) potentially programmed from embryonic stages.
  • The first 1,000 days (conception to two years) represent a critical window of opportunity for intervention due to heightened plasticity.
  • Optimal nutrition and a balanced intestinal microbiota are crucial for immune system development and preventing allergic diseases.

Purpose of the Study:

  • To highlight the critical role of the first 1,000 days in establishing long-term health.
  • To emphasize the importance of optimal nutrition and gut microbiota for preventing NCDs and allergic diseases.
  • To underscore the public health significance of early life interventions.

Main Methods:

  • This study is a review of existing scientific evidence.
  • Analysis of research on early life nutrition and its impact on development.
  • Examination of the role of intestinal microbiota in immune function and disease prevention.

Main Results:

  • Scientific evidence confirms the first 1,000 days are crucial for long-term health.
  • Optimal nutrition during this period significantly influences development and reduces NCD risk.
  • Intestinal microbiota plays a key role in immune maturation and preventing allergies.

Conclusions:

  • The first 1,000 days are a strategic period for public health interventions focused on nutrition and gut health.
  • Early life interventions can program better long-term health outcomes and prevent diseases.
  • Understanding host-microbiota interactions is vital for optimizing early life development.
Abstract

Keywords:
Nutrición temprana. Enfermedades no transmisibles. Obesidad. Enfermedades alérgicas. Microbiota intestinal. Sistema inmune.

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