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Updated: Jan 28, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer
Renate Slind Olsen1,2, Jan Dimberg3, Robert Geffers4
1a Department of Laboratory Medicine, Division of Medical Diagnostics , Region Jönköping County , Jönköping , Sweden.
Abstract:
Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.
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