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Multi-rhythmicity generated by coupling two cellular rhythms.

Jie Yan1,2, Albert Goldbeter2

  • 11 Center for Systems Biology, School of Mathematical Sciences, Soochow University , Suzhou , People's Republic of China.

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|March 7, 2019
PubMed
Summary
This summary is machine-generated.

The circadian clock and cell cycle can exhibit multiple stable rhythms (multi-rhythmicity) when coupled. Perturbations can switch between these states, revealing complex dynamics in biological systems.

Keywords:
biological rhythmsbirhythmicitymultiple attractorsoscillationstrirhythmicity

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Area of Science:

  • * Cellular biology
  • * Systems biology
  • * Chronobiology

Background:

  • * The cell cycle and circadian clock are fundamental cellular rhythms.
  • * Circadian clock regulates proteins involved in the mammalian cell cycle.
  • * Previous models showed cell cycle entrainment at 24h or 48h periods based on autonomous period and coupling strength.

Purpose of the Study:

  • * To investigate the potential for multiple stable periodic regimes (multi-rhythmicity) arising from the coupling of the cell cycle and circadian clock.
  • * To explore the conditions under which birhythmicity and trirhythmicity can emerge.
  • * To analyze the role of transient perturbations in switching between oscillatory states.

Main Methods:

  • * Utilized numerical simulations of a detailed model for coupled cellular rhythms.
  • * Analyzed the dynamics of the cell cycle under the influence of the circadian clock.
  • * Investigated the impact of transient perturbations on system state switching.

Main Results:

  • * Demonstrated that coupling the cell cycle and circadian clock can lead to multi-rhythmicity, including birhythmicity and trirhythmicity.
  • * Showed that transient perturbations can induce switching between different stable periodic regimes.
  • * Identified final state sensitivity in switching, linked to complex attraction basin structures.

Conclusions:

  • * Provides a novel instance of multi-rhythmicity in a realistic model of coupled cellular rhythms.
  • * Elucidates conditions for the coexistence of multiple stable periodic regimes in biological systems.
  • * Highlights the sensitivity of biological systems to perturbations for state transitions.