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Therapeutic Prospects in Preeclampsia - A Mini-Review.

N S Das1, S T Dheen1, E A Ling1

  • 1Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Current Medicinal Chemistry
|March 7, 2019
PubMed
Summary

Preeclampsia (PE) is a pregnancy complication with no current drug treatments. Researchers identified biomarkers like Corin and PP13, offering potential diagnostic and therapeutic avenues for this complex condition.

Keywords:
Preeclampsiaadenosinebiomarkerscorinhypertensionplacental protein 13.

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Area of Science:

  • Obstetrics and Gynecology
  • Biochemistry
  • Pathophysiology

Background:

  • Preeclampsia (PE) presents with hypertension, proteinuria, and edema during pregnancy, potentially leading to seizures.
  • Current management focuses on symptom regulation and delivery; no specific therapeutic drugs exist for PE.
  • Understanding PE's complex etiology is crucial for developing effective treatments.

Purpose of the Study:

  • To conduct a literature search for biomolecules associated with preeclampsia.
  • To identify potential diagnostic markers and therapeutic leads for PE.

Main Methods:

  • Literature review and analysis of scientific publications.
  • Identification and categorization of biomolecules linked to PE.

Main Results:

  • Biomolecules such as Corin and Placental Protein 13 (PP13) were identified as associated with PE.
  • The study provided insights into the mechanistic pathways involved in PE development.
  • PE is understood to result from an interplay of multiple factors, not a single cause.

Conclusions:

  • Identified biomarkers can enhance understanding of this complex disease.
  • These biomarkers may lead to the discovery of effective molecular targets for clinical trials.
  • Potential therapeutic options for pregnant women affected by PE could be developed.