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Equine thyroid function assessment with the thyrotropin-releasing hormone response test.

C D Lothrop, H L Nolan

    American Journal of Veterinary Research
    |April 1, 1986
    PubMed
    Summary

    Thyrotropin-releasing hormone (TRH) significantly boosts thyroid hormones thyroxine (T4) and triiodothyronine (T3) in horses and ponies. This suggests TRH can be a valuable diagnostic tool for equine thyroid function assessment.

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    Area of Science:

    • Veterinary Endocrinology
    • Equine Physiology

    Background:

    • Thyroid hormones, thyroxine (T4) and triiodothyronine (T3), regulate metabolism in horses.
    • The hypothalamic-pituitary-thyroid axis controls thyroid hormone release.

    Purpose of the Study:

    • To investigate the effect of thyrotropin-releasing hormone (TRH) on equine thyroid function.
    • To assess the potential of TRH as a diagnostic test for hypophysis-thyroid disorders in horses.

    Main Methods:

    • Adult horses (n=5) and ponies (n=6) received intravenous TRH (1 mg or 0.5 mg, respectively).
    • Serum concentrations of T4 and T3 were measured at multiple time points up to 24 hours post-administration.

    Main Results:

    • Serum T4 levels peaked at 4 hours post-TRH administration, increasing from a basal mean of 24.4 ng/ml to 48.2 ng/ml.

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  • Serum T3 levels peaked at 2 hours post-TRH administration, increasing from a basal mean of 0.44 ng/ml to 1.31 ng/ml.

    • Conclusions:

    • TRH administration effectively stimulates the release of T4 and T3 in horses and ponies.
    • TRH may serve as a useful diagnostic agent for evaluating equine hypophysis-thyroid function.