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Area of Science:

  • Gastroenterology
  • Endoscopic Procedures

Background:

  • Endoscopic retrograde cholangiopancreatography (ERCP) is vital for biliary and pancreatic diseases but has high complication rates.
  • Post-ERCP pancreatitis (PEP) is a common and potentially life-threatening complication following ERCP procedures.

Purpose of the Study:

  • To highlight effective strategies for the early and active prevention of post-ERCP pancreatitis.
  • To discuss current clinical approaches to minimize PEP incidence.

Main Methods:

  • Review of established and emerging prophylactic measures for PEP.
  • Analysis of the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs), pancreatic stent placement, and aggressive hydration.

Main Results:

  • Preoperative rectal NSAIDs and prophylactic pancreatic stent placement are established effective strategies.
  • Aggressive hydration with lactated Ringer's solution is identified as a safe and effective preventive measure.

Conclusions:

  • Early and active prevention significantly reduces the incidence of PEP.
  • A combination of pharmacological and procedural interventions, alongside supportive care like hydration, is key to managing ERCP risks.