Related Experiment Video
Updated: Jan 28, 2026
09:04
In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
6.9K
A retinal model of cerebral malaria
François Paquet-Durand1, Susanne C Beck2, Soumyaparna Das3
1Cell Death Mechanisms Lab, Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany. francois.paquet-durand@klinikum.uni-tuebingen.de.
Scientific Reports
|March 7, 2019
Summary
A novel mouse model of malaria retinopathy reveals parasite invasion of the retina and irreversible neurodegeneration. In vivo imaging aids early diagnosis and treatment development for this severe malaria complication.
Area of Science:
- * Tropical Medicine
- * Infectious Diseases
- * Ophthalmology
Background:
- * Malaria causes approximately 500,000 deaths annually worldwide.
- * Cerebral malaria is a severe, often fatal complication.
- * Malaria retinopathy shares pathophysiology with cerebral malaria.
Purpose of the Study:
- * To establish and characterize a preclinical model of malaria retinopathy.
- * To investigate parasite dynamics and retinal damage in vivo.
- * To evaluate anti-malarial treatment efficacy in this model.
Main Methods:
- * Development of a murine model of malaria retinopathy.
- * Non-invasive in vivo retinal imaging of GFP-labeled malaria parasites.
- * Assessment of retinal neurodegeneration and parasite load post-treatment.
Main Results:
- * Murine malaria retinopathy recapitulates key features of the human condition.
- * Malaria parasites were observed crossing the blood-retinal barrier and infiltrating the neuroretina.
- * Extensive, irreversible retinal neurodegeneration occurred, with partial resolution following dihydroartemisinin treatment.
Conclusions:
- * A novel, accessible preclinical model for cerebral malaria and retinopathy is presented.
- * In vivo retinal imaging is a valuable tool for studying disease pathophysiology.
- * The findings suggest potential for early diagnosis and novel therapeutic strategies.
More Related Videos
Related Concept Videos
01:05Cerebral Hemispheres
2.3K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.3K
02:00Molecular Models
43.7K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K
02:18The Bohr Model
80.7K
Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded by lighter and even tinier electrons continually moving about the nucleus was well established. This picture was called the planetary model since it pictured the atom as a miniature “solar system” with the electrons orbiting the nucleus like planets orbiting the sun. The simplest atom is hydrogen, consisting of a single proton as the...
80.7K
01:09Clearance Models: Physiological Models
310
Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
310
01:25Clearance Models: Compartment Models
305
Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume...
305
01:20Compartment Models: Two-Compartment Model
7.1K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
7.1K