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Neural correlates of early adversity among Bangladeshi infants

Sarah K G Jensen1,2, Swapna Kumar3, Wanze Xie3,4

  • 1Boston Children's Hospital, Boston, Massachusetts, USA. sarahkgeorg@gmail.com.

Scientific Reports
|March 7, 2019
PubMed

Insights

Visual Evoked Potential (VEP) P1 amplitude in Bangladeshi children is linked to cognitive development. Early VEP measures predict later cognitive scores, and caregiving impacts later VEP and cognitive function.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • Early childhood development is crucial for long-term cognitive outcomes.
  • Environmental factors, such as socioeconomic status and caregiving, significantly influence child development.
  • The Visual Evoked Potential (VEP) offers insights into neural processing and development.

Purpose of the Study:

  • To investigate the relationship between VEP P1 amplitude and cognitive function in young children in Bangladesh.
  • To examine the predictive value of VEP P1 amplitude for future cognitive development.
  • To explore the influence of caregiving experiences on VEP and cognitive outcomes.

Main Methods:

  • Collected VEPs (pattern-reversing checkerboards) from 6-month-old infants and 36-month-old children.
  • Assessed cognitive function using the Mullen Scales of Early Learning and Wechsler Preschool and Primary Scale of Intelligence.
  • Analyzed the association between VEP P1 amplitude, cognitive scores, and caregiving experiences.

Main Results:

  • VEP P1 amplitude correlated with concurrent cognitive performance in both age groups.
  • VEP P1 amplitude at 6 months predicted cognitive outcomes at 27 months.
  • VEP P1 amplitude at 36 months predicted IQ at 60 months.
  • Caregiving experiences influenced VEP P1 amplitude at 36 months and cognitive functioning.

Conclusions:

  • VEP P1 amplitude serves as a potential biomarker for neurodevelopmental trajectories.
  • Early adversity and caregiving experiences impact neurobiological development and cognitive function.
  • VEP measurements can help identify children at risk for cognitive impairments due to early life adversity.

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