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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
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Emerging epigenetic-modulating therapies in lymphoma

David Sermer1, Laura Pasqualucci2, Hans-Guido Wendel3

  • 1Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature Reviews. Clinical Oncology
|March 7, 2019
PubMed

Insights

New epigenetic therapies offer hope for lymphoma patients with poor prognoses. This review covers promising agents targeting histone deacetylases (HDACs), DNA methyltransferases (DNMTs), and other epigenetic regulators for improved lymphoma treatment.

Area of Science:

  • Oncology
  • Hematology
  • Epigenetics

Background:

  • Relapsed/refractory lymphoma patients have poor prognoses, necessitating novel therapeutic strategies.
  • Epigenetic dysregulation is a key driver in various cancers, including B cell and T cell lymphomas.
  • Epigenetic-modifying agents have emerged as a significant class of drugs in hematological malignancies.

Purpose of the Study:

  • To provide a concise overview of promising epigenetic therapies for lymphoma treatment.
  • To highlight emerging research directions in epigenetic therapy for lymphomas.

Main Methods:

  • Review of current literature on epigenetic therapies for lymphoma.
  • Focus on specific epigenetic targets including HDACs, DNMTs, EZH2, BETs, PRMTs, and IDHs.

Main Results:

  • Several classes of epigenetic agents show promise in preclinical and clinical settings for lymphoma.
  • Inhibitors targeting HDACs, DNMTs, EZH2, BETs, PRMTs, and IDHs are under investigation.
  • Ongoing research is identifying new therapeutic strategies and combinations.

Conclusions:

  • Epigenetic therapies represent a vital and evolving approach to treating lymphoma.
  • Targeting epigenetic mechanisms offers a promising avenue for improving outcomes in relapsed/refractory lymphoma.
  • Future research should focus on optimizing these therapies and exploring novel epigenetic targets.

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