Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

1.0K
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
1.0K
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

4.2K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
4.2K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

951
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
951
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

665
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
665
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

277
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
277
Pedigree Analysis01:35

Pedigree Analysis

89.1K
Overview
89.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frequency of massive diphenhydramine ingestions in children 6-18 years of age.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

Pharmacokinetic analysis of conventional tobramycin dosing for infants in the cardiac intensive care unit.

Pediatric research·2026
Same author

The Work That Changed Me: My Story of Growing Up and Overcoming Growing Pains Through Pediatric Pharmacy.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026
Same author

Pharmacist antithrombotic interventions in critically ill children: A multicenter prospective study.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same author

Optimal dosing of enoxaparin in children with CHD less than 1 year of age.

Cardiology in the young·2026
Same author

Bacterial Resistance Associated With Inhaled Tobramycin for Prevention of Ventilator-Associated Tracheitis in Mechanically Ventilated Neonates and Children Without Cystic Fibrosis: An Observational Pilot Study.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2026

Related Experiment Video

Updated: Jan 28, 2026

Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children – Working Memory (CABC-WM)
09:05

Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children – Working Memory (CABC-WM)

Published on: June 12, 2017

30.8K

Opioid Use in Children.

Kelly L Matson, Peter N Johnson, Van Tran

    The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
    |March 7, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Pharmacists play a crucial role in pediatric pain management by guiding appropriate opioid use and non-opioid alternatives. They also educate families on safe practices and support treatment for opioid use disorder in adolescents.

    Keywords:
    Opioid-Related DisordersOpioid-Related Disorders/prevention and controlmisuseopioidpediatricspharmacist

    More Related Videos

    Studying Brain Function in Children Using Magnetoencephalography
    08:00

    Studying Brain Function in Children Using Magnetoencephalography

    Published on: April 8, 2019

    9.6K
    Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
    04:55

    Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

    Published on: September 11, 2018

    11.2K

    Related Experiment Videos

    Last Updated: Jan 28, 2026

    Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children – Working Memory (CABC-WM)
    09:05

    Assessing Working Memory in Children: The Comprehensive Assessment Battery for Children – Working Memory (CABC-WM)

    Published on: June 12, 2017

    30.8K
    Studying Brain Function in Children Using Magnetoencephalography
    08:00

    Studying Brain Function in Children Using Magnetoencephalography

    Published on: April 8, 2019

    9.6K
    Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
    04:55

    Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

    Published on: September 11, 2018

    11.2K

    Area of Science:

    • Pharmacology
    • Pediatric Medicine
    • Public Health

    Background:

    • Limited established guidance for pediatric opioid use raises medication safety concerns.
    • Adolescent and young adult opioid misuse and opioid use disorder (OUD) are significant public health issues.
    • The Pediatric Pharmacy Advocacy Group (PPAG) emphasizes the need for pharmacist involvement in pediatric pain management.

    Purpose of the Study:

    • To outline recommendations for safe and effective opioid use in pediatric pain management.
    • To highlight the role of pharmacists in preventing and managing opioid-related issues in children and adolescents.
    • To advocate for evidence-based strategies in pediatric pain management and OUD treatment.

    Main Methods:

    • Review of current literature and guidelines on pediatric pain management and opioid use.
    • Development of recommendations by the Pediatric Pharmacy Advocacy Group (PPAG).
    • Emphasis on pharmacist-led education, screening, and referral processes.

    Main Results:

    • Pharmacists should guide the use of non-opioid pain alternatives and consider naloxone coprescribing.
    • Pharmacists should review electronic prescription drug-monitoring programs before opioid prescribing.
    • Pharmacist education on safe opioid administration, storage, disposal, and OUD awareness is vital for prevention.

    Conclusions:

    • Pharmacists are essential in optimizing pediatric pain management and mitigating risks associated with opioid use.
    • Improved access to evidence-based medications (methadone, buprenorphine, naltrexone) is encouraged for adolescents diagnosed with OUD.
    • Pharmacists should actively participate in screening for OUD and referring patients to appropriate treatment services.