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Zinc deficiency in children with Dengue viral infection

Lakkana Rerksuppaphol1, Sanguansak Rerksuppaphol2

  • 1Department of Preventive Medicine.

Pediatric Reports
|March 7, 2019
PubMed

Insights

Nearly half of Thai children hospitalized with dengue viral infection had zinc deficiency. Boys were at higher risk, and deficiency may prolong fever and hospital stays, warranting further research.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Nutritional Science

Background:

  • Zinc deficiency is a significant global health issue, particularly in low-income nations.
  • Impaired immunity due to zinc deficiency increases susceptibility to infections in children.
  • Dengue viral infection is a common childhood illness with potential severe outcomes.

Purpose of the Study:

  • To investigate the prevalence of zinc deficiency in Thai children diagnosed with dengue viral infection.
  • To explore the association between zinc deficiency and clinical outcomes in pediatric dengue patients.

Main Methods:

  • A cross-sectional study was conducted on 32 hospitalized Thai children with dengue viral infection.
  • Zinc levels were assessed using standard age, sex, time of blood collection, and fasting status cut-offs.
  • Statistical analysis included calculating odds ratios to assess risk factors.

Main Results:

  • The prevalence of zinc deficiency was 46.7% among the studied children.
  • Boys exhibited a significantly higher risk of zinc deficiency compared to girls (OR=7.3).
  • Children with zinc deficiency showed trends towards longer fever duration and hospital stays, though not statistically significant.

Conclusions:

  • Zinc deficiency is common in Thai children with dengue viral infection.
  • Boys appear to be more vulnerable to zinc deficiency in this context.
  • Further large-scale studies are recommended to confirm the link between zinc status and dengue clinical outcomes.

Keywords:
childrendengue diseasezinczinc deficiency

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