Related Experiment Video
Updated: Jan 28, 2026
05:52
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
13.1K
An Efficacious Endometrial Sampler for Screening Endometrial Cancer
Lu Han1,2, Jiang Du3, Lanbo Zhao4
1Center for Single-Cell Biology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Frontiers in Oncology
|March 7, 2019
Summary
The Li Brush endometrial sampler shows promise for early detection of endometrial cancer. This minimally invasive tool demonstrated high accuracy in screening, making it an effective option for cancer diagnosis.
Area of Science:
- Gynecology
- Oncology
- Pathology
Background:
- Early detection of endometrial cancer is crucial for improved patient outcomes.
- Minimally invasive screening procedures are increasingly preferred for endometrial cancer detection.
Purpose of the Study:
- To evaluate the feasibility and efficacy of the Li Brush endometrial sampler for screening endometrial cancer.
- To compare the diagnostic accuracy of the Li Brush sampler against histopathologic diagnosis.
Main Methods:
- A self-controlled trial involving 293 women undergoing hysterectomy.
- Endometrial cells were collected using the Li Brush prior to surgery.
- Cytopathologic diagnosis from Li Brush was compared with histopathologic diagnosis from hysterectomy specimens.
Main Results:
- Sensitivity (Se): 92.73%
- Specificity (Sp): 98.15%
- Positive Predictive Value (PV+): 92.73%
- Negative Predictive Value (PV-): 98.15%
Conclusions:
- The Li Brush endometrial sampler is an effective instrument for screening endometrial cancer.
- The study validates the use of Li Brush as a reliable tool for early detection of endometrial malignancies.
Related Concept Videos
01:29Self-Efficacy
219
Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
219
01:22Dose-Response Relationship: Potency and Efficacy
6.5K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.5K
02:46Genetic Screens
5.7K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.7K
02:18Cancer
54.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.2K
02:12What is Cancer?
14.4K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
01:30Cancer Vaccines
1.0K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.0K