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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis.

Adam W Turner1, Doris Wong1,2, Mohammad Daud Khan1

  • 1Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States.

Frontiers in Cardiovascular Medicine
|March 7, 2019
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Summary

Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in atherosclerosis. Understanding lncRNA function and regulation is crucial for developing new diagnostic markers and therapeutic targets for cardiovascular diseases.

Keywords:
atherosclerosiscardiovascular diseasegene regulationgenomicslong noncoding (lnc) RNAs

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Area of Science:

  • Molecular Biology
  • Genomics
  • Cardiovascular Research

Background:

  • Atherosclerosis is a complex inflammatory disease involving multiple cell types in the vessel wall.
  • Genome-wide association studies (GWAS) and next-generation sequencing have identified numerous long non-coding RNAs (lncRNAs) potentially involved in disease pathogenesis.

Purpose of the Study:

  • To review the documented functional roles of lncRNAs in atherosclerosis.
  • To discuss novel genomics approaches for studying lncRNA functions and interactions.
  • To highlight methods for analyzing lncRNA spatial and temporal regulation and available computational tools.

Main Methods:

  • Review of traditional biochemical approaches and high-throughput assays (e.g., RNA-sequencing) for lncRNA identification.
  • Description of novel genomics techniques for investigating lncRNA interactions with DNA, RNA, and proteins.
  • Summary of assays for assessing lncRNA spatial and temporal regulation.
  • Overview of computational tools for lncRNA genomic and functional annotation.

Main Results:

  • Several lncRNAs with well-documented roles in atherosclerosis have been identified.
  • Advancements in genomics and high-throughput assays facilitate the discovery and characterization of lncRNAs.
  • Novel methods are available to study lncRNA regulation and interactions.

Conclusions:

  • Deep characterization of lncRNAs is fundamental to understanding atherosclerosis and other cardiovascular diseases.
  • lncRNAs represent a new class of potential therapeutic targets and diagnostic markers.
  • Understanding lncRNAs can help mitigate genetic and environmental risk factors for cardiovascular diseases.