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Baseline Cerebral Small Vessel Disease Is Not Associated with Gait Decline After Five Years

Helena M van der Holst1, Ingeborg W M van Uden1, Karlijn F de Laat2

  • 1Department of Neurology Radboud University Medical Center Donders Institute for Brain, Cognition and Behaviour Centre for Neuroscience Reinier Postlaan 4 Nijmegen 6500HB The Netherlands.

Movement Disorders Clinical Practice
|March 7, 2019
PubMed

Insights

Baseline cerebral small vessel disease (SVD) markers did not predict gait decline in older adults over five years. Future research should examine if SVD progression impacts gait deterioration.

Area of Science:

  • Neurology
  • Geriatrics
  • Radiology

Background:

  • Cerebral small vessel disease (SVD) is linked to gait disturbances, but its impact on long-term gait decline is unclear.
  • Diffusion tensor imaging (DTI) studies specifically examining gait decline in SVD are limited.

Purpose of the Study:

  • To investigate the association between baseline SVD imaging markers and subsequent gait decline.
  • To explore the relationship between SVD and incident gait impairment over a 5-year period.

Main Methods:

  • Prospective cohort study of 310 older adults (aged 50-85) with SVD from the RUN DMC cohort.
  • Gait variables assessed using a computerized walkway at baseline and follow-up.
  • Linear/logistic regression and tract-based spatial statistics (TBSS) analyzed imaging markers, gait decline, and DTI measures.

Main Results:

  • No significant associations were found between baseline SVD imaging markers and gait decline over 5 years.
  • Tract-based spatial statistics (TBSS) showed no significant differences in DTI measures between participants with and without incident gait impairment after adjusting for SVD.
  • Sub-analyses indicated potential associations between high white matter hyperintensity (WMH) volumes and gait impairment risk, though not statistically significant after multiple testing correction.

Conclusions:

  • Baseline SVD imaging markers are not associated with gait decline or incident gait impairment over a 5-year follow-up.
  • Further research is needed to determine if the progression of SVD, rather than baseline markers, is related to gait deterioration.
Abstract

Keywords:
cerebral small vessel diseasediffusion tensor imaginggaitmagnetic resonance imaging

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