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Resting-state Functional MRI in Parkinsonian Syndromes

Massimo Filippi1,2, Elisabetta Sarasso1,3, Federica Agosta1

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy.

Movement Disorders Clinical Practice
|March 7, 2019
PubMed
Abstract

Insights

Resting-state functional MRI (fMRI) reveals brain connectivity changes in Parkinson's disease (PD) and related disorders. This technique shows promise for early detection, diagnosis, and monitoring treatment response in movement disorders.

Area of Science:

  • Neuroimaging
  • Clinical Neuroscience
  • Movement Disorders

Background:

  • Functional MRI (fMRI) is utilized to examine aberrant functional connectivity patterns at rest in patients with movement disorders like idiopathic Parkinson's disease (PD) and atypical parkinsonisms.
  • Resting-state fMRI offers insights into the neural mechanisms of motor and non-motor symptoms in parkinsonian syndromes.

Purpose of the Study:

  • To provide an educational review of the current applications of resting-state fMRI in the study of parkinsonian syndromes.
  • To highlight the potential of resting-state fMRI as a biomarker for early disease detection, prediction, and differential diagnosis.

Main Methods:

  • Review of existing literature on resting-state fMRI studies in parkinsonian syndromes.
  • Analysis of how resting-state fMRI contributes to understanding disease mechanisms and therapeutic monitoring.

Main Results:

  • Resting-state fMRI has enhanced understanding of motor and non-motor symptom development and progression in movement disorders.
  • Resting-state fMRI shows potential as a biomarker for early disease detection, prediction, differential diagnosis, and monitoring treatment efficacy.

Conclusions:

  • There is a critical need for validated prodromal biomarkers in PD.
  • Further research is required to differentiate overlapping and disease-specific fMRI abnormalities across parkinsonian syndromes.
  • Continued technical advancements are essential to fully leverage fMRI for monitoring chronic therapy efficacy.
Keywords:
Parkinson's disease (PD)atypical parkinsonismsfunctional MRI (fMRI)magnetic resonance imaging (MRI)resting‐state

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