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5-Endo-dig cyclizations in organic syntheses.

Muhammad Aamir Sajid¹, Zulfiqar Ali Khan², Sohail Anjum Shahzad³

¹Department of Chemistry, Faculty of Physical Sciences, Government College University, Faisalabad, 38000, Pakistan.

Molecular Diversity

|March 7, 2019

Summary

Baldwin rules highlight the importance of ring closure reactions. This review details recent applications of 5-endo-dig cyclization in synthesizing five-membered heterocycles and carbocycles over the past two decades.

Keywords:

5-Endo-dig cyclization 5-Membered carbocycles 5-Membered heterocyles Electrophilic cyclizations

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Area of Science:

Organic Chemistry
Synthetic Organic Chemistry

Background:

Baldwin's rules are crucial for predicting the feasibility of ring closure reactions.
Recent literature demonstrates a growing interest in ring closure methodologies.
5-endo-dig cyclization is a key transformation in modern organic synthesis.

Purpose of the Study:

To review recent advancements in 5-endo-dig cyclization reactions.
To highlight the synthetic utility of this method in organic synthesis.
To cover applications within the last two decades.

Main Methods:

Literature review of research articles, reviews, and books.
Focus on studies published in the last 20 years.
Analysis of synthetic strategies employing 5-endo-dig cyclization.

Main Results:

Demonstration of 5-endo-dig cyclization for synthesizing diverse 5-membered heterocycles.
Synthesis of various carbocyclic compounds using this methodology.
Compilation of key applications and synthetic achievements.

Conclusions:

5-endo-dig cyclization is a versatile and important reaction in organic synthesis.
This method enables the efficient construction of valuable cyclic structures.
The review provides a comprehensive overview of recent progress in the field.