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Changes in left ventricular repolarization after short-term testosterone replacement therapy in hypogonadal males
G Piccirillo1, F Moscucci2, R Pofi3
1Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, Policlinico Umberto I, "La Sapienza" University of Rome, Viale del Policlinico, 00185, Rome, Italy.
Journal of Endocrinological Investigation
|March 7, 2019
Summary
Hypogonadal patients exhibit prolonged myocardial repolarization at rest, but this does not increase sudden cardiac death risk. Testosterone replacement therapy partially improves repolarization markers.
Area of Science:
- Cardiology
- Endocrinology
- Electrophysiology
Background:
- Androgen deficiency is linked to sudden cardiac death (SCD).
- Hypogonadism may affect cardiac repolarization.
- Electrocardiographic (ECG) markers can indicate repolarization abnormalities.
Purpose of the Study:
- To analyze ECG repolarization markers in hypogonadal patients.
- To compare repolarization in hypogonadal patients versus controls.
- To assess the impact of testosterone replacement therapy (TRT) on repolarization.
Main Methods:
- 14 hypogonadal patients and 10 controls underwent ECG recordings.
- ECGs were taken at rest and post-maximal exercise.
- Parameters analyzed included QTe, QTp, and Te intervals.
Main Results:
- Hypogonadal patients had longer QTe and QTp at rest compared to controls.
- QTp remained longer during recovery in hypogonadal patients.
- TRT improved Te intervals, but QTp-Te coherence worsened during recovery.
Conclusions:
- Hypogonadal patients show stable repolarization prolongation at rest.
- Increased temporal dispersion of repolarization was not observed.
- The risk of sudden cardiac death in hypogonadal patients appears low.
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