Related Experiment Video

Updated: Jan 28, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.3K

Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia

Chuwen Li1,2, Yaqi Bian2, Yu Feng2

  • 1Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences , Guangzhou Medical University , Guangzhou 510182 , China.

ACS Chemical Neuroscience
|March 7, 2019
PubMed

Insights

BHDPC offers significant neuroprotection in stroke models by reducing brain damage and neuronal loss. It modulates microglial polarization and impacts NF-κB and PKA/CREB signaling pathways for therapeutic benefits.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cell Biology

Background:

  • Ischemic stroke remains a leading cause of death and disability worldwide.
  • Understanding the mechanisms of neuroprotection is crucial for developing effective therapies.
  • Microglial activation and polarization play a significant role in ischemic stroke pathology.

Purpose of the Study:

  • To investigate the therapeutic effects of BHDPC on ischemic stroke.
  • To elucidate the underlying mechanisms of BHDPC's neuroprotective actions.
  • To explore BHDPC's impact on microglial activation and polarization.

Main Methods:

  • In vivo transient middle cerebral artery occlusion (MCAO) model in mice.
  • In vitro oxygen-glucose deprivation/reperfusion (OGD/R) models using BV-2 microglia, primary neurons, and bEnd.3 endothelial cells.
  • Analysis of neurological deficits, brain infarcts, neuronal apoptosis, blood-brain barrier integrity, microglial polarization, NF-κB, PKA, and CREB signaling.

Main Results:

  • BHDPC significantly alleviated neurological deficits, brain infarcts, and neuronal loss in MCAO mice.
  • BHDPC inhibited M1 microglial activation and promoted M2 polarization in both in vivo and in vitro models.
  • BHDPC's effects were linked to the inactivation of NF-κB and activation of PKA/CREB signaling pathways.

Conclusions:

  • BHDPC demonstrates potent neuroprotective effects against ischemic stroke.
  • Modulation of microglial activation and polarization is a key mechanism underlying BHDPC's efficacy.
  • The neuroprotective actions of BHDPC are mediated, in part, by the NF-κB and PKA/CREB signaling pathways.
Keywords:
BHDPCCREBNF-κBPKAischemic strokemicroglia

More Related Videos

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.9K
Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model08:53

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Published on: December 9, 2018

7.7K

Related Concept Videos

Group Polarization01:01

Group Polarization

Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
39.2K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

Dipole Moment of a Molecule
75.4K
Bond Polarity, Dipole Moment, and Percent Ionic Character02:48

Bond Polarity, Dipole Moment, and Percent Ionic Character

Bond Polarity
35.4K
Polarity of the Cytoskeleton01:18

Polarity of the Cytoskeleton

The intrinsic polarity of cells can be primarily attributed to two factors- i) the asymmetric accumulation of mobile components such are regulatory molecules and subcellular components across the cell and ii) the orientation of polar cytoskeletal filaments that make up the cytoskeletal networks, specifically microfilaments, and microtubules arranged along the axis of polarity. Interactions between the cytoskeletal filaments are crucial for the establishment and maintenance of the polar nature...
25.2K
Polar Covalent Bonds02:24

Polar Covalent Bonds

Covalent bonds are formed between two atoms when both have similar tendencies to attract electrons to themselves (i.e., when both atoms have identical or fairly similar ionization energies and electron affinities). Nonmetal atoms frequently form covalent bonds with other nonmetal atoms. For example, the hydrogen molecule, H2, contains a covalent bond between its two hydrogen atoms. When two separate hydrogen atoms with a particular potential energy approach each other, their valence orbitals...
29.0K
Dielectric Polarization in a Capacitor01:31

Dielectric Polarization in a Capacitor

The presence of a dielectric medium in a capacitor not only changes the voltage and capacitance but also affects the electric field. In general, dielectrics can be of two types: polar and nonpolar. In a polar dielectric, the positive and negative charges in the molecules are separated by a distance and hence have a permanent dipole moment. In contrast, no such charge separation exists in a nonpolar dielectric, however the nonpolar molecules get polarized in the presence of an external electric...
6.0K