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Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach
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Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders

Evert Njomen1, Jetze J Tepe1

  • 1Department of Chemistry, and Pharmacology & Toxicology , Michigan State University , East Lansing , Michigan 48824 , United States.

Journal of Medicinal Chemistry
|March 7, 2019
PubMed

Insights

Enhancing proteasome activity combats protein aggregation linked to aging and neurodegenerative diseases. This review explores methods to boost proteasome function for therapeutic benefits.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Molecular Medicine

Background:

  • Proteasomes are crucial for degrading damaged proteins, maintaining cellular function and protein homeostasis.
  • Aging and neurodegenerative diseases are associated with decreased proteasome activity and protein accumulation.
  • Protein aggregation is a hallmark of neurodegenerative disorders and cancers.

Purpose of the Study:

  • To review current strategies for enhancing proteasome activity.
  • To discuss challenges and explore therapeutic applications of increased proteasome function.
  • To highlight the potential of proteasome enhancement beyond aging and neurodegeneration.

Main Methods:

  • Review of existing literature on proteasome activity enhancement.
  • Analysis of genetic manipulation techniques.
  • Examination of posttranslational modification strategies.
  • Evaluation of small molecule proteasome agonists.

Main Results:

  • Multiple approaches exist to increase proteasome activity, including genetic, posttranslational, and pharmacological methods.
  • Enhancing proteasome function shows therapeutic potential for proteotoxic disorders.
  • The field of proteasome enhancement is relatively unexplored with significant potential.

Conclusions:

  • Increasing proteasome activity is a promising therapeutic strategy for age-related and neurodegenerative diseases.
  • Further research is needed to overcome challenges and fully realize the therapeutic potential of proteasome enhancement.
  • Applications extend beyond neurodegeneration to various proteotoxic conditions.

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