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Biomolecular Detection employing the Interferometric Reflectance Imaging Sensor IRIS
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Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager.

Filiz Yesilkoy1, Roland A Terborg2, Josselin Pello2

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Summary
This summary is machine-generated.

This study introduces a novel plasmonics-enhanced biosensing platform. It leverages phase-sensitive detection for ultrasensitive, label-free biomarker identification, ideal for point-of-care diagnostics.

Keywords:
interferometric imaginglabel-free plasmonic biosensorslens-free imagingphase interrogationpoint-of-care devicesprotein microarray detection

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Area of Science:

  • Plasmonics and Nanophotonics
  • Biomolecular Sensing
  • Optical Metasurfaces

Background:

  • Plasmonic resonances offer enhanced light-matter interactions for biosensing.
  • Current methods primarily detect spectral shifts, neglecting phase response.
  • Exploiting phase response requires complex optical setups.

Purpose of the Study:

  • To develop a phase-sensitive platform for high-throughput, label-free plasmonics-enhanced biosensing.
  • To enable ultrasensitive detection of atomically thin topographical features.
  • To create a cost-effective and scalable solution for biomarker detection.

Main Methods:

  • Utilized specifically designed gold (Au) nanohole arrays.
  • Employed a large field-of-view interferometric lens-free imaging reader.
  • Implemented a collinear optical path configuration for phase detection.

Main Results:

  • Demonstrated detection of angstrom-level topographical features over large areas.
  • Enabled simultaneous reading of thousands of microarray elements.
  • Achieved high-throughput and label-free detection.

Conclusions:

  • The developed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes.
  • Scalable fabrication and low-cost components make it suitable for widespread application.
  • Opens new avenues for on-site disease diagnostics and remote health monitoring.