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Asymmetric total synthesis of (+)-asenapine
Piotr Szcześniak1, Olga Staszewska-Krajewska, Jacek Mlynarski
1Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland. alchemik_84@tlen.pl.
Abstract:
Asymmetric total synthesis of (+)-asenapine, an atypical antipsychotic drug, used for treating schizophrenia and acute mania associated with bipolar disorder, is reported. The key steps are the organocatalytic Michael addition of aldehydes to trans-nitroalkenes and subsequent reductive cyclization.
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