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Updated: Jan 28, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
Published on: October 5, 2014
Analysis of Collagen-Binding Integrin Interactions with Supramolecular Aggregates of the Extracellular Matrix
1Institute of Musculoskeletal Medicine, University Hospital Münster, Münster, Germany. uhansen@uni-muenster.de.
Abstract:
Integrin-mediated interactions of cells with the extracellular matrix (ECM) are important for their activities. The ECM itself is a complex network of macromolecules forming aggregates or suprastructures. Moreover, the molecular composition is important for the macromolecular organization and, thereby, the functional properties of the ECM. In addition, collagen molecules lose their integrin-binding capabilities after incorporation into fibrils. Therefore, we have established detailed protocols for the analysis of integrin-matrix interactions at the supramolecular level.
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