[SU.VI.MAX and NutriNet-Santé: lessons from large cohorts]

Area of Science:

• Epidemiologic studies
• Nutritional science
• Public health research

Background:

• Two large French studies, SU.VI.MAX intervention trial and NutriNet-Santé web-based cohort, provide insights into nutrition and health.
• SU.VI.MAX investigated antioxidant supplementation's effect on cancer prevention.
• NutriNet-Santé examines the complex relationship between diet, lifestyle, and health outcomes.

Purpose of the Study:

• To present findings from the SU.VI.MAX and NutriNet-Santé studies.
• To explore the impact of antioxidant supplementation on cancer incidence.
• To investigate determinants of dietary patterns and nutritional status.

Main Methods:

• SU.VI.MAX: Randomized, double-blind, placebo-controlled trial of antioxidant supplementation for 7.5 years.
• NutriNet-Santé: Web-based prospective cohort study initiated in 2009.
• Both studies utilized detailed nutritional and health outcome assessments.

Main Results:

• SU.VI.MAX: Daily antioxidant supplementation reduced total cancer incidence in men, but not women.
• Gender-specific differences in baseline antioxidant status may explain the observed effects.
• Cancer incidence may be influenced by baseline antioxidant status and individual health profiles.

Conclusions:

• Antioxidant supplementation effects on cancer prevention can be gender and status-dependent.
• Further research is needed to understand the multifaceted determinants of dietary patterns and health.
• Large cohort studies are crucial for advancing nutritional epidemiology.