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Updated: Jan 28, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
The protective effect of Lactobacillus plantarum against meticillin-resistant Staphylococcus aureus infections: an
Mehmet Sürmeli1, Salih Maçin2, Yakut Akyön3
1Plastic, Reconstructive and Aesthetic Surgery Specialist, Istanbul Bağcilar Research and Training Hospital, Merkez Mah, Department of Plastic, Reconstructive and Aesthetic Surgery, 34200 Bağcilar, Istanbul, Turkey.
Objective:
To determine and quantitatively measure the protective and/or therapeutic effect of Lactobacillus plantarum (LP) application on a burn wound before and after the onset of meticillin-resistant Staphylococcus aureus (MRSA) infection.
Method:
Third-degree scald burns affecting 10% of body surface area were formed on the back of five groups of rats. Group 1 was designated as the control group. In Group 2, LP was applied immediately after the burn and then MRSA inoculated. In Group 3, MRSA was applied immediately after the burn and then LP inoculated. Groups 4 and 5 were designated as controls of LP and MRSA. On the fifth and tenth days, bacterial loads and compositions were assessed by tissue biopsies.
Results:
Each group contained seven rats (n=35). In Group 2, MRSA colony counts were found to be significantly lower compared with the other groups (p<0.05). In Group 3, MRSA colony counts were not found to be significantly different compared with control groups (p>0.05).
Conclusion:
LP was shown to have a protective role in non-infected, burn wounds when applied before MRSA infection but a therapeutic effect of LP was not demonstrated. LP is thought to have a promising role in the prevention and treatment of burn wound infections.
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