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Variation in algorithm implementation across radiomics software.

Joseph J Foy1, Kayla R Robinson1, Hui Li1

  • 1University of Chicago, Department of Radiology, Chicago, Illinois, United States.

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|March 7, 2019
PubMed
Summary
This summary is machine-generated.

Radiomics software variations cause inconsistent quantitative image analysis. Standardizing radiomics processes is crucial for reliable results in medical imaging analysis.

Keywords:
head and neck CTmammographyradiomicssoftware packagestexture analysis

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Area of Science:

  • Medical Imaging Analysis
  • Quantitative Imaging
  • Radiomics

Background:

  • Quantitative image analysis in medical imaging is increasingly important.
  • Variations in radiomics software can lead to inconsistent feature calculations.
  • Standardization is needed for reliable radiomics analysis.

Purpose of the Study:

  • To investigate radiomics feature calculation variations across different software packages.
  • To compare results from in-house and freely available radiomics software.
  • To identify sources of discrepancies in radiomics feature extraction.

Main Methods:

  • Utilized two in-house and two public radiomics packages (MaZda, IBEX).
  • Analyzed 40 ROIs from mammograms and 39 ROIs from head and neck CT scans.
  • Calculated first-order histogram and second-order GLCM features.
  • Employed Friedman tests and ICC for statistical analysis.

Main Results:

  • Significant differences and systematic biases observed in first-order features across packages, though agreement was generally excellent.
  • Second-order GLCM features showed significant differences and poor agreement due to default parameter discrepancies.
  • Variations attributed to preprocessing, algorithms, and naming conventions.

Conclusions:

  • Substantial variations exist in radiomics features calculated by different software.
  • Discrepancies in second-order features are particularly notable.
  • Standardization of radiomics software and processes is urgently required for clinical applications.