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A New Transkingdom Dimension to NO Signaling
1Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR5242, UCBL1, Lyon, France.
Cell Metabolism
|March 7, 2019
Summary
Microbiota produce nitric oxide that modifies host Argonaute proteins. This bacterial metabolite impacts gene silencing via the microRNA (miRNA) pathway, affecting host physiology.
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- Bacterial metabolites significantly impact host physiology.
- Microbiota-derived molecules play crucial roles in host-microbe interactions.
- Post-transcriptional gene regulation is essential for cellular function.
Purpose of the Study:
- To investigate the mechanism by which bacterial metabolites influence host gene regulation.
- To explore the role of nitric oxide in mediating host-microbe crosstalk.
- To understand the impact of microbiota on the microRNA (miRNA) machinery.
Main Methods:
- Interspecies S-nitrosylation assays.
- Analysis of Argonaute protein activity.
- Investigation of microRNA (miRNA) pathway function.
- Assessment of host cellular and organismal physiology.
Main Results:
- Microbiota-derived nitric oxide directly modifies host Argonaute proteins via S-nitrosylation.
- Altered Argonaute activity impacts the post-transcriptional gene silencing program.
- The microRNA (miRNA) machinery is directly affected by bacterial nitric oxide.
Conclusions:
- Bacterial nitric oxide is a key mediator of host gene regulation.
- Microbiota can directly modulate host gene expression through metabolite signaling.
- This cross-kingdom communication influences host physiology via the miRNA pathway.
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