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"Deepening" Insight on Skin Aging and Anti-microbial Immunity
Tetsuro Kobayashi1, Keisuke Nagao1
1Cutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Cell Metabolism
|March 7, 2019
Abstract:
Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired anti-bacterial host defense.