Thyrotropin-releasing hormone (TRH) and circulatory shock

Recent research has focused on the potential role of the central nervous system (CNS) in the pathophysiology of circulatory shock. Although the precise role of the brain in shock remains controversial, a number of neuropeptides--through actions within the CNS--appear to play a role in mediating cardiovascular responses to a variety of shock states. Thyrotropin-releasing hormone (TRH) is a neuropeptide that has potent cardiovascular effects within the CNS. Recently, it has been used successfully to reverse shock of varying etiologies in a number of species. Here we review the cardiovascular actions of TRH, its interaction with endogenous opiate systems, and its potential role in the treatment of circulatory shock.