Related Experiment Video

Updated: Jan 28, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

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HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer

Gabriel Rinnerthaler1,2, Simon Peter Gampenrieder3,4, Richard Greil5,6

  • 1Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University Salzburg, 5020 Salzburg, Austria. g.rinnerthaler@salk.at.

International Journal of Molecular Sciences
|March 8, 2019
PubMed

Insights

HER2-targeted therapies have improved breast cancer outcomes. New antibody-drug conjugates show promise for HER2-amplified and HER2-expressing breast tumors, expanding treatment options.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver in a subset of breast cancers.
  • HER2-directed therapies have significantly improved the prognosis of HER2-amplified breast cancers.
  • Trastuzumab emtansine (T-DM1) is a key antibody-drug conjugate for advanced HER2-positive breast cancer.

Purpose of the Study:

  • To review preclinical and clinical evidence of investigational HER2-directed antibody-drug conjugates.
  • To explore new therapeutic options for HER2-amplified and HER2-expressing breast tumors.

Main Methods:

  • Review of current preclinical data.
  • Analysis of ongoing clinical investigations.

Main Results:

  • Several novel HER2-directed antibody-drug conjugates are under clinical investigation.
  • These agents target both HER2-amplified and HER2-expressing, but not amplified, breast tumors.

Conclusions:

  • Investigational antibody-drug conjugates represent a promising frontier in HER2-targeted breast cancer therapy.
  • These new agents may offer expanded treatment avenues for a broader range of HER2-positive breast cancer patients.
Keywords:
(vic-)trastuzumab duocarmazineADCHER2 lowHM2-MMAETAK-522Trastuzumab deruxtecanTrastuzumab emtansineanti-HER2/PBD-MAmode of action

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