Related Experiment Video

Updated: Jan 28, 2026

Driving Under the Influence: How Music Listening Affects Driving Behaviors
07:25

Driving Under the Influence: How Music Listening Affects Driving Behaviors

Published on: March 27, 2019

13.1K

Challenges of driving CD30-directed CAR-T cells to the clinic

Natalie S Grover1, Barbara Savoldo2

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA. Natalie_grover@med.unc.edu.

BMC Cancer
|March 8, 2019
PubMed

Insights

Chimeric antigen receptor T (CAR-T) cell therapy targeting CD30 shows promise for relapsed lymphomas. Ongoing trials aim to improve CAR-T cell persistence and efficacy for better patient outcomes.

Area of Science:

  • Immunotherapy
  • Oncology
  • Hematology

Background:

  • Chimeric antigen receptor T (CAR-T) cell therapy is a novel treatment for hematologic malignancies.
  • CD19-targeted CAR-T cells have shown success, but alternative targets are needed for CD19-negative lymphomas.
  • CD30 is expressed across various lymphoma subtypes, making it a viable target.

Purpose of the Study:

  • To evaluate the feasibility and efficacy of CD30-directed CAR-T cell therapy.
  • To explore CD30 as a therapeutic target for relapsed or refractory lymphomas.
  • To identify strategies for enhancing CAR-T cell persistence and anti-tumor activity.

Main Methods:

  • Preclinical studies assessing CD30-directed CAR-T cell activity.
  • Clinical trials involving patients with relapsed/refractory CD30+ lymphomas.
  • Analysis of treatment toxicities and preliminary efficacy.

Main Results:

  • Preclinical data support the feasibility of CD30-CAR-T cell therapy.
  • Early clinical trials demonstrate minimal toxicity and preliminary efficacy in a subset of patients.
  • CD30-directed CAR-T cells offer a potential treatment option for lymphomas lacking CD19 expression.

Conclusions:

  • CD30-directed CAR-T cell therapy is a promising approach for CD30-positive lymphomas.
  • Enhancing CAR-T cell persistence and expansion is crucial for improved treatment outcomes.
  • Future research will focus on optimizing treatment regimens and exploring combination therapies.
Keywords:
Anaplastic large cell lymphomaCD30Cellular immunotherapyChimeric antigen receptor T cellsHodgkin lymphoma

More Related Videos

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo05:14

Studying Interactions between Myeloid Cells and CAR T Cells In Vitro and In Vivo

Published on: July 25, 2025

837
Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells07:56

Using CRISPR/Cas9 to Knock Out GM-CSF in CAR-T Cells

Published on: July 22, 2019

11.9K

Related Concept Videos

Energy to Drive Translocation01:37

Energy to Drive Translocation

Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
2.8K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.5K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.6K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.9K
Drive-Reduction Theory: Push Theory of Motivation01:27

Drive-Reduction Theory: Push Theory of Motivation

Clark Hull's drive-reduction theory, introduced in the 1940s and 1950s and often termed the "push theory" of motivation, provides a framework for understanding how biological and learned drives influence behavior. Hull suggested that motivation originates from the need to alleviate physiological tension caused by unmet biological necessities. The theory proposes that when a basic need, such as hunger or sleep, goes unfulfilled, it creates an internal imbalance. This imbalance, or...
1.2K