Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

667
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
667
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.5K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.5K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

202
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
202
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

266
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
266
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

242
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
242

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disconnects between knowledge and practice in antimicrobial resistance stewardship: findings from Vietnam's National AMR survey.

npj antimicrobials and resistance·2026
Same author

Cost-effectiveness of a real-time screening strategy for bacterial vaginosis using qPCR to prevent preterm birth: results from a randomized prospective multicenter study.

Cost effectiveness and resource allocation : C/E·2026
Same author

Young adults with PIMD Polyhandicap in pediatric settings a situation more complex than problematic.

Scientific reports·2026
Same author

Kidney biopsy during pregnancy: indications, complications, results and therapeutic impact.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Ciliary Beat Frequency and Pattern: An Accessible Tool for the Screening of Primary Ciliary Dyskinesia.

Diagnostics (Basel, Switzerland)·2026
Same author

Effects of deep brain stimulation on non motor fluctuations in Parkinson's disease (assessed with the NMF severity scale).

Clinical parkinsonism & related disorders·2026

Related Experiment Video

Updated: Jan 28, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.1K

Polyhandicap and aging.

Marie-Christine Rousseau1, Thierry Billette de Villemeur2, Sherezad Khaldi-Cherif3

  • 1Fédération des Hôpitaux de Polyhandicap et Multihandicap Hôpital San Salvadour, Assistance Publique Hôpitaux de Paris, France; EA 3279, Self-perceived Health Assessment Research Unit, School of Medicine, Aix Marseille Université, 27 Bd Jean Moulin, Marseille, 13385, France.

Disability and Health Journal
|March 8, 2019
PubMed
Summary

This study describes the health status and care needs of individuals with severe and complex disabilities. Improved care is enhancing longevity, with some surviving over 50 years.

Keywords:
AgeingComorbiditiesHealth statusMedicationsPolyhandicapRehabilitation procedures

More Related Videos

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K
Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

507

Related Experiment Videos

Last Updated: Jan 28, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.1K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K
Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

507

Area of Science:

  • Gerontology and disability studies.
  • Neurology and rehabilitation medicine.

Background:

  • Limited knowledge exists on the health status and care management of elderly individuals with polyhandicap (severe and complex disabilities).
  • Understanding the aging process in individuals with severe and complex disabilities is crucial for optimizing care strategies.

Purpose of the Study:

  • To characterize individuals aged 18-68 with severe and complex disabilities.
  • To describe their health status, including medications, medical devices, and rehabilitation procedures.

Main Methods:

  • An 18-month cross-sectional study involving 474 participants aged 18-68 years.
  • Participants had a combination of severe motor deficiency and profound intellectual impairment.
  • Data collected included aetiology of disability, health status, medical devices, and rehabilitation procedures.

Main Results:

  • Behavioral disorders and pain were more prevalent in older age groups (50-68 years).
  • Elderly individuals had more severe but less unstable disabilities.
  • Gastrostomy was the most common medical device required.

Conclusions:

  • Longevity for individuals with severe and complex disabilities is increasing.
  • Improved preventive actions and supportive care contribute to survival beyond 50 years for some individuals.
  • Individuals with less unstable conditions and fewer comorbidities show greater longevity.