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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

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Histone Deacetylase Inhibitors and Anaplastic Thyroid Carcinoma

Eleftherios Spartalis1, Dimitrios I Athanasiadis2, Dimosthenis Chrysikos3

  • 1Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, Medical School, National and Kapodistrian University of Athens, Athens, Greece eleftherios.spartalis@gmail.com.

Anticancer Research
|March 8, 2019
PubMed
Abstract

Insights

Histone deacetylase inhibitors (HDACI) show promise for treating anaplastic thyroid cancer (ATC), an aggressive malignancy. Research indicates HDACI are effective as standalone treatments or in combination therapies for ATC management.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Anaplastic thyroid cancer (ATC) is a highly aggressive and often incurable human malignancy.
  • Histone deacetylases (HDAC) are implicated in regulating gene transcription within ATC.
  • HDAC inhibitors (HDACI) are emerging as potential therapeutic agents for ATC.

Purpose of the Study:

  • To review the efficacy of HDAC inhibitors in treating anaplastic thyroid cancer.
  • To outline current research trends concerning HDACIs in ATC.

Main Methods:

  • A literature review was conducted using the MEDLINE database.
  • Search terms included "thyroid cancer," "anaplastic," "HDAC," "histone," "deacetylase*," and "HDACI."

Main Results:

  • Numerous compounds, including valproic acid, trichostatin A, panobinostat, belinostat, and others, demonstrated significant antitumor activity against ATC.
  • Specific compounds like SuberoylAnilide Hydroxamic Acid, AB1-13, MS-275, depsipeptide, CUDC101, CUDC907, HNHA, and PXD101 were highlighted for their effects.

Conclusions:

  • HDAC inhibitors represent a promising therapeutic strategy for managing anaplastic thyroid cancer.
  • HDACIs show potential efficacy when used as monotherapy or in combination with other anticancer agents.
Keywords:
HDACanaplasticcancerhistone deacetylase inhibitorsreviewthyroid

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