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Updated: Jan 28, 2026

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Published on: December 1, 2016
Post-treatment Glasgow Prognostic Score Predicts Efficacy in Advanced Non-small-cell Lung Cancer Treated With
Norimitsu Kasahara1, Noriaki Sunaga2, Yusuke Tsukagoshi2
1Innovative Medical Research Center, Gunma University Hospital, Maebashi, Japan m14702016@gunma-u.ac.jp.
Background/Aim:
No definitive biomarker exists for predicting treatment efficacy or response to therapy with antibody to programmed cell death-1 (PD1) for patients with advanced non-small cell lung cancer (NSCLC). Hence, we investigated whether the Glasgow prognostic score (GPS) predicted anti-PD1 treatment response for advanced NSCLC.
Patients And Methods:
This study retrospectively identified 47 patients with NSCLC treated with anti-PD1 and assessed the prognostic value of the GPS. The GPS was calculated using C-reactive protein and albumin concentrations 1 month after starting anti-PD1 treatment. Kaplan-Meier method and Cox proportional hazard models were used to examine differences in progression-free (PFS) and overall (OS) survival, and clinical response.
Results:
The post-treatment GPS independently predicted anti-PD1 treatment efficacy, as a good post-treatment GPS (GPS 0-1) was significantly associated with improved PFS. Intra-treatment GPS change was associated with clinical response.
Conclusion:
The post-treatment GPS independently predicted efficacy of anti-PD1 treatment for NSCLC.
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