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Carboplatin Plus Nab-paclitaxel in Performance Status 2 Patients With Advanced Non-small-cell Lung Cancer
Kazuhisa Nakashima1, Hiroaki Akamatsu2, Haruyasu Murakami3
1Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan ka.nakashima@scchr.jp.
Background/Aim:
This phase I/II study aimed at assessing the efficacy of combination therapy with carboplatin (CBDCA) on day 1 and nab-paclitaxel (Nab-PTX) on days 1 and 8 of a 21-day cycle in performance status (PS) 2 patients with non-small-cell lung cancer (NSCLC).
Patients And Methods:
PS 2 patients with NSCLC were enrolled into a phase I study using a 3 + 3 design. Once the recommended phase II dose (RP2D) was established, the patients were enrolled into phase II.
Results:
Based on the phase I findings, the RP2D was determined as CBDCA area under the curve 6 mg/ml/min and Nab-PTX 100 mg/m2 In the phase II part, 27 patients were evaluable. The overall response rate was 44%. The median progression-free survival and overall survival were 5.2 months and 14.0 months, respectively. There was no treatment-related death.
Conclusion:
CBDCA plus Nab-PTX therapy is a promising treatment strategy for PS 2 patients with NSCLC.
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