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Effectiveness of Intensity-Modulated Radiotherapy for Rectal Cancer Patients Treated With Neoadjuvant Concurrent
Chia-Chin Li1, Ji-An Liang1,2, Chih-Yuan Chung3
1Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Background/Aim:
Neoadjuvant concurrent chemoradiotherapy (nCCRT) is the standard of care for locally advanced rectal cancer (LARC) patients treated with neoadjuvant concurrent chemoradiotherapy (nCCRT). The aim of this study was to compare intensity-modulated radiotherapy (IMRT) to 3D conformal radiotherapy (3DCRT) in nCCRT patients.
Patients And Methods:
We identified LARC patients diagnosed from 2007 to 2015 through the Taiwan cancer registry (TCR) and we constructed a propensity score matched cohort to compare IMRT to 3DCRT after balancing observable potential confounders. We compared the hazard ratio (HR) of death as well as other endpoints between the IMRT and 3DCRT. We performed supplementary analysis (SA) when additional potential confounders were considered.
Results:
Our study population consisted of 696 patients. There was no statistical difference when IMRT was compared to 3DCRT (HR for death=1.01, 95%confidence interval(CI)=0.76-1.35, p=0.93). There were also no statistical differences for the other endpoints or SA.
Conclusion:
For LARC patients treated with nCCRT, the treatment outcome has no statistically significant benefit between those treated with IMRT or 3DCRT.
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