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Association between serum thyrotropin within the euthyroid range and obesity.
Xiuying Zhang1, Yufeng Li2, Xianghai Zhou1
1Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Centre, Beijing 100044, China.
Endocrine Journal
|March 8, 2019
Summary
Thyroid stimulating hormone (TSH) within the normal range is linked to higher body mass index (BMI) and obesity risk. Menopause significantly influences this thyroid function and obesity association.
Area of Science:
- Endocrinology
- Public Health
- Obesity Research
Background:
- The link between thyroid function and obesity is debated, particularly within the normal reference range.
- Understanding these associations is crucial for public health and metabolic disease management.
Purpose of the Study:
- To investigate the relationship between serum thyrotropin (TSH) levels within the normal range and obesity indices.
- To evaluate potential modifying factors, such as menopause, in the TSH-obesity association.
Main Methods:
- Analysis of a large community cohort in Beijing, China (1,816 men, 1,774 women).
- Inclusion criteria: serum TSH levels within the reference range (0.55-4.78 μIU/mL).
- Statistical analyses included correlation, ANOVA, Chi-square, and logistic regression.
Main Results:
- Serum TSH within the reference range showed a positive association with Body Mass Index (BMI) in both genders.
- Individuals with TSH in the upper quartile had significantly higher odds of obesity and severe obesity compared to those in the middle quartile.
- In postmenopausal women, lower TSH levels were associated with a reduced risk of severe obesity.
Conclusions:
- Elevated serum TSH levels, even within the normal euthyroid range, are positively associated with obesity.
- Menopause status significantly modifies the relationship between TSH levels and severe obesity risk in women.
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