Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse

Anna D Senft1, Elizabeth K Bikoff1, Elizabeth J Robertson2

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.

Nature Communications
|March 8, 2019
PubMed

Related Concept Videos

Nodal Analysis01:10

Nodal Analysis

Nodal analysis is a fundamental method in electrical engineering used to simplify the process of circuit analysis. This method revolves around the concept of using node voltages as the primary variables for circuit analysis. The objective is to determine the voltage at each node in a circuit, which can then be used to find other quantities of interest, such as currents through specific components.
Consider, for instance, a simple circuit composed of three nodes and three resistors, as shown in...
1.9K
Nodal Analysis with Voltage Sources01:11

Nodal Analysis with Voltage Sources

Nodal analysis is a remarkably effective method used in electrical engineering to simplify the analysis of complex circuits, including those with dependent or independent voltage sources. Its strength lies in its systematic approach to breaking down circuits into manageable components, making it easier for engineers to understand and solve.
Consider a circuit that contains four resistors and two voltage sources, as shown in Figure 1. One of these voltage sources is connected between a...
1.9K
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.3K
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.2K
Requirements for Human Life01:26

Requirements for Human Life

The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
13.4K
Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.7K