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Updated: Jan 28, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
Published on: September 5, 2018
Scaling and correlation properties of RR and QT intervals at the cellular level
Jiyeong Kim1, Disheet Shah2, Ilya Potapov3
1Computational Physics Laboratory, Tampere University, Tampere, Finland. jiyeong.kim@tuni.fi.
Abstract:
We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincaré plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in the short- and long-term scaling exponents α1 and α2 of RR and QT intervals and their cellular equivalences. Previously unknown scaling properties of FPDs of hiPSC-CM aggregates reveal that the increasing scaling exponent of QT intervals as a function of the time scale, is an intrinsic feature at the cellular level.
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