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Updated: Jan 28, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Enantioselective and site-specific copper-catalyzed reductive allyl-allyl cross-coupling of allenes
Guoxing Xu1, Bin Fu1, Haiyan Zhao1
1Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis , Department of Chemistry , Northeast Normal University , Changchun , 130024 , Jilin , China .
Abstract:
A copper-catalyzed asymmetric reductive allyl-allyl cross-coupling reaction of allenes with allylic phosphates wherein allenes were used as allylmetal surrogates has been achieved for the first time. This protocol provides an efficient and straightforward route to optically active 1,5-dienes in a highly enantioselective and site-specific fashion. Furthermore, all-carbon quaternary stereogenic centers could also be constructed with this protocol. The versatility of the products is demonstrated through a diverse array of further transformations of the enantioenriched 1,5-dienes.
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