Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-surface Signaling01:21

Cell-surface Signaling

54.2K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.2K
The Cell Cycle Control System01:28

The Cell Cycle Control System

5.5K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.5K
The Cell Cycle Control System02:11

The Cell Cycle Control System

14.2K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
14.2K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

27.2K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
27.2K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A blood-brain barrier model based on flexible tubes to tailor the biophysical and chemical environment for drug delivery testing.

Materials today. Bio·2026
Same author

Nature's blueprint: Exopolysaccharides linking microbiome dynamics to advanced bone tissue engineering.

Carbohydrate polymers·2026
Same author

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Unraveling the potential and challenges of photosynthetic microalgae for oxygenating engineered tissues.

Biomaterials advances·2026
Same author

Superbase ionic liquid mediated solubilization of curcumin for improved bioavailability and anticancer efficacy.

Scientific reports·2026
Same author

Stable Protein-Based G-Quadruplex-Derived Supramolecular Bioinks as Tunable ECM-Mimetic Constructs Assembled by Combining Non-Covalent and Covalent Strategies.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Spatial Patterning of Micromotor Aggregation and Flux.

ChemNanoMat : chemistry of nanomaterials for energy, biology and more·2024
Same journal

Electrospun Nanofibers for Wound Management.

ChemNanoMat : chemistry of nanomaterials for energy, biology and more·2022
Same journal

Phytotoxic effect of sub-3-nm crystalline ceria nanoparticles on the hydroponic growth of Daikon radish microgreens.

ChemNanoMat : chemistry of nanomaterials for energy, biology and more·2022
Same journal

Nanotechnology Toolkit for Combating COVID-19 and Beyond.

ChemNanoMat : chemistry of nanomaterials for energy, biology and more·2022
Same journal

Enzymatic Delivery of Magnetic Nanoparticles into Mitochondria of Live Cells.

ChemNanoMat : chemistry of nanomaterials for energy, biology and more·2021
Same journal

Flexible and Stretchable PEDOT-Embedded Hybrid Substrates for Bioengineering and Sensory Applications.

ChemNanoMat : chemistry of nanomaterials for energy, biology and more·2021
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Protein Engineering by Yeast Surface Display
05:49

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

3.5K

Cell surface engineering to control cellular interactions.

Catarina A Custódio1,2, João F Mano1,2

  • 13B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence of Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal.

Chemnanomat : Chemistry of Nanomaterials for Energy, Biology and More
|March 8, 2019
PubMed
Summary
This summary is machine-generated.

Cell surface engineering modifies cell membranes to control cell functions like adhesion and migration. This review explores biological, chemical, and physical methods for cell surface manipulation and its applications.

More Related Videos

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.8K
Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
12:22

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Published on: March 1, 2016

8.7K

Related Experiment Videos

Last Updated: Jan 28, 2026

Protein Engineering by Yeast Surface Display
05:49

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

3.5K
Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

2.8K
Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering
12:22

Preparation of Thermoresponsive Nanostructured Surfaces for Tissue Engineering

Published on: March 1, 2016

8.7K

Area of Science:

  • Biotechnology
  • Cell Biology
  • Materials Science

Background:

  • Cell surface composition dictates cellular interactions with the environment.
  • Cell membranes offer a versatile platform for molecular modification.
  • Cell surface engineering presents challenges due to the complexity and dynamic nature of cell surfaces, requiring strategies that maintain cell viability.

Purpose of the Study:

  • To review recent advancements in cell surface engineering.
  • To explore methods for modulating cell functions and interactions through cell surface modification.
  • To highlight potential applications of engineered cell surfaces.

Main Methods:

  • Review of biological, chemical, and physical approaches for cell surface engineering.
  • Discussion of techniques including chemical conjugation, functional group modification, and introduction of exogenous ligands (recombinant proteins, liposomes, nanoparticles).
  • Focus on strategies compatible with cell viability.

Main Results:

  • Cell surface engineering enables the creation of novel cell-cell and cell-microenvironment interactions.
  • Modification of cell surface composition can effectively control cell functions such as adhesion and migration.
  • Diverse ligands and methods can be employed to achieve desired surface modifications.

Conclusions:

  • Cell surface engineering is a powerful tool for controlling cell behavior and interactions.
  • The review highlights the potential of engineered cell surfaces across various applications.
  • Further research in this field promises significant advancements in biotechnology and medicine.