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WITHDRAWN: Interventions for treating obesity in children.
Hiltje Oude Luttikhuis1, Louise Baur, Hanneke Jansen
1Beatrix Children's Hospital and Department of Epidemiology, University Medical Center Groningen, PO Box 30.001 (CA80), 9700RB, Groningen, Netherlands.
The Cochrane Database of Systematic Reviews
|March 8, 2019
Summary
Lifestyle interventions significantly reduce overweight in children and adolescents. Drug therapies like orlistat or sibutramine may aid obese adolescents but require careful consideration of side effects.
Area of Science:
- Pediatrics
- Public Health
- Evidence-Based Medicine
Background:
- Child and adolescent obesity is a growing global health concern.
- Obesity in youth is linked to immediate and long-term health issues.
Purpose of the Study:
- To evaluate the effectiveness of lifestyle, pharmaceutical, and surgical methods for treating childhood obesity.
Main Methods:
- Systematic review of 64 randomized controlled trials (RCTs) published between 1985 and May 2008.
- Included interventions: lifestyle (diet, physical activity, behavioral), and drug therapies (metformin, orlistat, sibutramine).
- Excluded: interventions for eating disorders, type 2 diabetes, or syndromic obesity.
Main Results:
- Lifestyle interventions showed significant reductions in overweight at 6 and 12 months for children and adolescents.
- Drug interventions (orlistat, sibutramine) combined with lifestyle changes also reduced overweight in adolescents.
- Adverse effects were reported with drug interventions.
Conclusions:
- Combined behavioral lifestyle interventions are effective for reducing overweight in children and adolescents.
- Orlistat or sibutramine may be considered as adjuncts for obese adolescents, balancing efficacy against potential adverse effects.
- Further high-quality research is needed on psychosocial factors, clinician-family interactions, and cost-effective community programs.
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