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Updated: Jan 28, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
Microbiota Diversity in Human Colorectal Cancer Tissues Is Associated with Clinicopathological Features
1a Department of Gastroenterology , Central Hospital of Dazhou City , Sichuan , China.
Aim:
Few evidences are available regarding the link between microbiota composition in the human colorectal cancer (CRC) tissues and the patients' clinicopathological features.
Methods:
Microbiota diversity in CRC tissues (n = 30) were profiled and compared by high-throughput sequencing with clinicopathological features, including tumor location, differentiation degree, metastasis, and CRC patients' gender and age.
Results:
Many bacteria with significant difference in abundance were identified associated with these clinicopathological features (P < 0.05). There was a significant difference in microbial composition between right colon cancers (RCa) vs. left colon cancers (LCa), RCa vs. rectal cancers (P < 0.05). The amount of Fusobacteria was significantly higher in LCa, moderately and poorly differentiated cancers (MPD), and young patients (<60 years), compared to RCa, well differentiated cancers (WD) and elder patients (>60 years), respectively (P < 0.05). Helicobacter spp. in RCa and MPD patients was significantly higher than in LCa and WD patients (P < 0.05). Firmicutes in non-lymph node metastasis (LNM) patients was significantly lower than in LNM patients (P < 0.05).
Conclusion:
The different microbiota composition in the CRCs was associated with patients' clinicopathological features, which could be a consequence of microflora diversity.
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