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Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Changes in body composition and weight during the menopause transition.

Gail A Greendale¹, Barbara Sternfeld², MeiHua Huang¹

¹Department of Medicine, Division of Geriatrics, UCLA, Los Angeles, California, USA.

|March 8, 2019

Summary

The menopause transition (MT) significantly alters body composition, accelerating fat gain and lean mass loss. These changes occur independently of aging, highlighting the MT

Keywords:

Aging Epidemiology Metabolism Obesity

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Published on: February 20, 2020

Area of Science:

Reproductive Endocrinology
Body Composition Research
Women's Health Studies

Background:

The relationship between menopause transition (MT) and body composition changes is not well understood.
This study investigates the impact of MT on body composition, independent of chronological aging.

Purpose of the Study:

To determine the influence of the menopause transition on body composition and weight.
To analyze changes in fat and lean mass relative to the final menstrual period (FMP).

Main Methods:

Utilized data from the longitudinal Study of Women's Health Across the Nation (SWAN) cohort.
Assessed body composition using dual-energy x-ray absorptiometry (DXA).
Employed multivariable mixed-effects regressions to model changes over time relative to FMP.

Main Results:

Fat mass and lean mass increased before the MT.
The rate of fat gain doubled, and lean mass declined at the onset of MT, continuing for two years post-FMP.
Weight increased linearly before MT and stabilized afterward, with no acceleration at MT onset.

Conclusions:

Accelerated fat mass gain and lean mass loss are directly associated with the menopause transition.
Despite body composition shifts, the overall rate of weight gain does not change significantly at the start of MT.