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Updated: Jan 28, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
735
Adjuvant therapy in high-risk prostate cancer
Jeffrey Shevach1, Parul Chaudhuri1, Alicia K Morgans2
1Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Clinical Advances in Hematology & Oncology : H&O
|March 8, 2019
Summary
High-risk localized prostate cancer poses challenges despite advances. New risk stratification and novel hormonal therapies offer hope for improved adjuvant treatment strategies in men with this aggressive disease.
Area of Science:
- Oncology
- Urology
- Genomics
Background:
- Localized prostate cancer generally has a good prognosis, but high-risk disease can lead to significant morbidity and mortality after treatment failure.
- Current systemic adjuvant therapy for high-risk prostate cancer is limited, primarily to androgen deprivation therapy.
Purpose of the Study:
- To explore advancements in risk stratification for high-risk localized prostate cancer.
- To discuss the potential of novel hormonal therapies in the adjuvant setting for improving treatment outcomes.
Main Methods:
- Review of clinicopathologic features and genomic data for risk stratification.
- Analysis of emerging novel hormonal therapies for advanced prostate cancer.
Main Results:
- Novel risk stratification methods combining clinicopathologic and genomic data enable more precise study of adjuvant therapies.
- Emerging hormonal therapies show promise for more effective adjuvant treatment options.
Conclusions:
- Improved risk stratification is crucial for developing targeted adjuvant therapies in high-risk prostate cancer.
- Novel hormonal therapies represent a potential paradigm shift in managing high-risk localized prostate cancer, offering new hope for patients.
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