Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

38.9K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
38.9K
Initiation of Translation02:33

Initiation of Translation

8.1K
8.1K
Nursing Implementation01:15

Nursing Implementation

6.1K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.1K
Transcription Initiation01:47

Transcription Initiation

20.8K
Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
20.8K
What is an Experiment?01:12

What is an Experiment?

17.7K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
17.7K
S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

5.6K
The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary Artery Bypass Grafting versus Percutaneous Coronary Intervention for Stable Multivessel Coronary Disease in the Current Era.

The Annals of thoracic surgery·2026
Same authorSame journal

Addressing barriers to care: A proposed model to predict prolonged treatment time among patients with locally advanced cervical cancer.

Brachytherapy·2026
Same author

Pursuit of advanced fellowships by thoracic surgery residents.

JTCVS open·2026
Same author

Initial Experience of Non-Atriotomy Surgical Ablation During Coronary Artery Bypass Grafting With Preexisting Atrial Fibrillation: A Multicenter Study.

Annals of thoracic surgery short reports·2026
Same author

The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2026 Update on Outcomes and Research.

The Annals of thoracic surgery·2026
Same author

Gender pay disparities among academic faculty - a slow healing wound.

American journal of surgery·2026
Same journal

EM-tracked MR-US live fusion and needle location in gynecologic brachytherapy.

Brachytherapy·2026
Same journal

Contour and dosimetric evaluation of an in-room mobile CBCT scanner for cylinder based brachytherapy.

Brachytherapy·2026
Same journal

Brachytherapy for rectal cancer: An overview of clinical competency development in contemporary practice.

Brachytherapy·2026
Same journal

Deep learning-based automatic segmentation of rectal tumors in endoscopic images.

Brachytherapy·2026
Same journal

Online educational program for CT-based image-guided adaptive brachytherapy in cervical cancer: The BrachyAcademy experience.

Brachytherapy·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
07:13

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Published on: March 26, 2014

23.9K

Implementation of an HDR brachytherapy-based breast IORT program: Initial experiences.

Sunil W Dutta1, J Hunter Mehaffey2, Jason C Sanders1

  • 1Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA.

Brachytherapy
|March 9, 2019
PubMed
Summary
This summary is machine-generated.

Precision breast intraoperative radiation therapy (PB-IORT) is a novel, safe, and feasible treatment for early-stage breast cancer. This approach shows increased surgical volume and patient demand, supporting further research.

Keywords:
BreastCTCancerHDRIORTIntraoperativeLumpectomyPartialRadiotherapybrachytherapy

More Related Videos

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data
04:13

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data

Published on: November 13, 2019

12.8K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

4.1K

Related Experiment Videos

Last Updated: Jan 28, 2026

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
07:13

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Published on: March 26, 2014

23.9K
Computer-based Multitaper Spectrogram Program for Electroencephalographic Data
04:13

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data

Published on: November 13, 2019

12.8K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

4.1K

Area of Science:

  • Oncology
  • Radiotherapy
  • Surgical Oncology

Background:

  • Early-stage breast cancer treatment often involves whole-breast irradiation.
  • Novel approaches are needed to optimize radiotherapy delivery and patient outcomes.
  • Precision breast intraoperative radiation therapy (PB-IORT) has been developed as a targeted treatment option.

Purpose of the Study:

  • To report the development and implementation experience of a novel PB-IORT program.
  • To evaluate the feasibility, safety, and impact of PB-IORT on institutional practice.
  • To assess patient interest and demand for this innovative breast cancer treatment.

Main Methods:

  • A multidisciplinary team developed PB-IORT using high-dose-rate brachytherapy and CT on-rails imaging.
  • A literature review was conducted, and patient data from 2010-2017 were analyzed, stratifying into pre- and post-IORT eras.
  • Surgical and radiation therapy volumes were analyzed using linear regression; patient travel distance was calculated.

Main Results:

  • Phase 1 trial data indicated PB-IORT is feasible and safe, meeting primary endpoints.
  • PB-IORT delivery costs exceed those of 16-fraction whole-breast irradiation due to supplies.
  • A significant increase in yearly breast cancer surgical volume was observed post-PB-IORT implementation.

Conclusions:

  • Accrual rates for the ongoing Phase II PB-IORT trial are exceeding expectations.
  • Rapid accrual suggests significant patient interest and demand for PB-IORT.
  • The findings support the feasibility of conducting further randomized trials to gather more data.